Table 3.
Top 10 most significant genes for extraversion and neuroticism, and symptoms of anxiety, depression and psychological distress, as evaluated by VEGAS. Genome-wide significant genes (in bold) were tested in an independent Australian cohort (replication P-value is shown in parentheses).
| Gene | Chromosome | Start Position |
Stop Position |
# of SNPs |
P-value |
|---|---|---|---|---|---|
| Extraversion | |||||
| PNMA1 | 14 | 73248238 | 73250881 | 77 | 6.00 × 10−6 |
| C14orf43 | 14 | 73251577 | 73323649 | 124 | 3.00 × 10−5 |
| DNAL1 | 14 | 73181330 | 73238402 | 104 | 6.10 × 10−5 |
| CRTC3 | 15 | 88874201 | 88989581 | 184 | 1.38 × 10−4 |
| KIAA0146 | 8 | 48336094 | 48811028 | 94 | 1.78 × 10−4 |
| SLC35F1 | 6 | 118335381 | 118745532 | 487 | 3.88 × 10−4 |
| SLC7A11 | 4 | 139304697 | 139382953 | 88 | 6.83 × 10−4 |
| PCBP1 | 2 | 70168204 | 70169836 | 52 | 7.57 × 10−4 |
| PAP2D | 1 | 99128388 | 99243037 | 207 | 8.18 × 10−4 |
| ASPRV1 | 2 | 70040727 | 70042901 | 72 | 8.41 × 10−4 |
| Neuroticism | |||||
| C15orf171 | 15 | 72979380 | 72986515 | 30 | 1.00 × 10−6 (0.048) |
| POLR3A | 10 | 79405909 | 79459265 | 55 | 1.00 × 10−6 (0.588) |
| MPI1 | 15 | 72969462 | 72977618 | 34 | 1.00 × 10−6 (0.046) |
| SCAMP21 | 15 | 72924249 | 72952723 | 55 | 1.00 × 10−6 (0.049) |
| ULK31 | 15 | 72915511 | 72922605 | 53 | 1.00 × 10−6 (0.047) |
| COX5A | 15 | 72999669 | 73017548 | 31 | 2.00 × 10−6 (0.046) |
| CPLX3 | 15 | 72906003 | 72911189 | 53 | 3.00 × 10−6 |
| LMAN1L | 15 | 72892246 | 72905152 | 63 | 7.00 × 10−6 |
| RPP25 | 15 | 73034495 | 73036828 | 32 | 7.00 × 10−6 |
| CSK | 15 | 72861477 | 72882592 | 67 | 1.70 × 10−5 |
| Anxiety | |||||
| RTTN | 18 | 65822020 | 66023942 | 251 | 1.02 × 10−4 |
| ST8SIA1 | 12 | 22237591 | 22378915 | 261 | 2.45 × 10−4 |
| FAM110B | 8 | 59069666 | 59224831 | 261 | 3.57 × 10−4 |
| KMO | 1 | 239762302 | 239825567 | 135 | 3.75 × 10−4 |
| MMRN1 | 4 | 91035074 | 91094803 | 128 | 6.28 × 10−4 |
| RPS28 | 19 | 8292383 | 8293280 | 41 | 6.28 × 10−4 |
| KANK3 | 19 | 8293467 | 8314146 | 45 | 7.12 × 10−4 |
| CHML | 1 | 239858789 | 239865855 | 66 | 7.57 × 10−4 |
| OPN3 | 1 | 239823074 | 239870324 | 121 | 7.61 × 10−4 |
| FAM82B | 8 | 87553693 | 87590125 | 117 | 8.32 × 10−4 |
| Depression | |||||
| GRAP | 17 | 18864714 | 18891061 | 23 | 1.90 × 10−5 |
| ARMC1 | 8 | 66677627 | 66708986 | 89 | 4.50 × 10−5 |
| MTFR1 | 8 | 66719527 | 66785340 | 98 | 4.70 × 10−5 |
| TTRAP | 6 | 24758183 | 24775094 | 126 | 6.30 × 10−5 |
| THEM2 | 6 | 24775253 | 24809921 | 127 | 6.80 × 10−5 |
| NDE1 | 16 | 15651604 | 15726491 | 85 | 1.00 × 10−4 |
| KIAA0430 | 16 | 15595744 | 15644510 | 54 | 1.18 × 10−4 |
| KIAA0319 | 6 | 24652310 | 24754362 | 229 | 2.35 × 10−4 |
| PDE7A | 8 | 66793866 | 66916297 | 84 | 2.70 × 10−4 |
| FAM83G | 17 | 18815105 | 18848785 | 59 | 3.23 × 10−4 |
| Psychological Distress |
|||||
| ARID3A | 19 | 877036 | 923803 | 79 | 2.10 × 10−5 |
| GRIN3B | 19 | 951436 | 960723 | 75 | 2.60 × 10−5 |
| WDR18 | 19 | 935327 | 945569 | 70 | 3.20 × 10−5 |
| VGLL2 | 6 | 117693413 | 117701421 | 116 | 7.50 × 10−5 |
| C19orf6 | 19 | 960649 | 972141 | 71 | 8.40 × 10−5 |
| EPOR | 19 | 11349474 | 11356019 | 36 | 1.84 × 10−4 |
| HMGB2 | 4 | 174489361 | 174492167 | 51 | 2.54 × 10−4 |
| C19orf39 | 19 | 11346382 | 11348627 | 37 | 2.87 × 10−4 |
| RGL3 | 19 | 11366000 | 11391004 | 41 | 2.87 × 10−4 |
| KISS1R | 19 | 868341 | 872015 | 54 | 2.96 × 10−4 |
1
The best-SNP association was rs11630918