Figure 2.

Peak DV titers in rhesus macaque BMs is markedly lower than that of humans. BMs were acquired and infected as previously described (Clark et al., 2012). Samples from Days 1 through 14 were quantified by realtime PCR. Human (red) and monkey (green) titers are depicted in RNA copy numbers per ml. The in vitro experimentation of whole BM indicates that human BM is able to produce far more virus than monkey BM. Titers appear to max out on average closer to Day 1 in monkey BM but reach their peak (~1000-fold higher) on Day 3 PI in humans.