Table 1.

Patient characteristics (n = 201) and association with Cdx2 expression in tumor.

Feature		Frequency N (%)	Frequency N (%)	Frequency N (%)	p-Value
		Total	Focal Cdx2	Diffuse Cdx2
Gender (n = 201)	Male	125 (62.2)	51 (59.3)	74 (64.4)	0.4655
	Female	76 (37.8)	35 (40.7)	41 (35.7)
Age (years) (n = 201)	Median (range)	72.0 (19–91)	70.9 (19–90)	73 (48–91)	0.0825
Tumor location (n = 200)	Left	76 (38.0)	28 (32.9)	48 (41.7)	0.3806
	Rectum	29 (14.5)	12 (14.1)	17 (14.8)
	Right	95 (47.5)	45 (52.9)	50 (43.5)
Histological subtype (n = 200)	Non-mucinous	162 (81.0)	62 (72.1)	100 (87.7)	0.0053
	Mucinous	38 (19.0)	24 (27.9)	14 (12.3)
Tumor grade (n = 199)	G1–2	140 (70.4)	48 (56.5)	92 (80.7)	0.0002
	G3	59 (29.6)	37 (43.5)	22 (19.3)
pT (n = 201)	pT1–2	47 (23.4)	13 (15.1)	34 (29.6)	0.0166
	pT3–4	154 (76.6)	73 (84.9)	81 (70.4)
pN (n = 200)	pN0	92 (46.0)	32 (37.2)	60 (52.6)	0.0303
	pN1–2	108 (54.0)	54 (62.8)	54 (47.4)
Metastasis (n = 190)	cM0	133 (70.0)	50 (63.3)	83 (74.8)	0.0887
	cM1	57 (30.0)	29 (36.7)	28 (25.2)
Perineural invasion (n = 111)	Absence	97 (87.4)	38 (79.2)	59 (93.7)	0.0228
	Presence	14 (12.6)	10 (20.8)	4 (6.4)
Venous invasion (n = 132)	Absence	59 (44.7)	21 (37.5)	38 (50.0)	0.1534
	Presence	73 (55.3)	35 (62.5)	38 (50.0)
Lymphatic invasion (n = 128)	Absence	32 (25.0)	10 (17.5)	22 (31.0)	0.0809
	Presence	96 (75.0)	47 (82.5)	49 (69.0)
Adjuvant therapy (n = 197)	None	135 (68.5)	48 (57.8)	87 (76.3)	0.0058
	Treated	62 (31.5)	35 (42.2)	27 (23.7)
Mismatch repair status (n = 201)	Proficient	174 (86.6)	60 (69.8)	114 (99.1)	<0.0001
	Deficient	27 (13.4)	26 (30.2)	1 (0.9)
Overall survival (n = 93)	Median (95%CI)	54.6 (28–72)	26.4 (10–61)	68.7 (44–101)	0.0145