Table 3.
Variable | Category | Number (n) | Disease-Free Survival | Overall Survival | ||
---|---|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | |||
Margin status | Clear | 17 | 1.0 | 0.05 | 1.0 | 0.03 |
Involved | 7 | 3.74 (0.98, 14.34) | 4.4 (1.11, 17.4) | |||
Size | <5 cm | 13 | 1.0 | 0.09 | 1.0 | 0.38 |
>5 cm | 11 | 2.79 (0.84, 9.25) | 1.63 (0.54, 4.9) | |||
Age at diagnosis | <50 | 12 | 1.0 | 0.77 | 1.0 | 0.3 |
>50 | 18 | 0.85 (0.29, 2.5) | 1.73 (0.64, 4.66) | |||
FNCLCC Grade | Lowintermed high | 5 | - | NS | - | NS |
23 | ||||||
Gender | Male | 20 | 1.0 | 0.16 | 1.0 | 0.18 |
Female | 10 | 0.46 (0.16, 1.35) | 0.51 (0.19, 1.37) | |||
Site | Scalp/face | 19 | 1.0 | 0.31 | 1.0 | 0.97 |
Parotid/neck | 7 | 0.77 (0.20, 2.93) | 0.61 (0.17, 2.18) | |||
Upper Airway | 4 | 2.40 (0.69, 8.32) | 1.32 (0.36, 4.78) | |||
Extension | Superficial | 4 | 1.0 | 0.1 | 1.0 | 0.97 |
Deep | 26 | 1.49 (0.19, 11.37) | 0.98 (0.28, 3.45) | |||
Radiation | No | 10 | 1.0 | 0.14 | 1.0 | 0.07 |
Primary | 2 | 1.78 (0.32, 9.78) | 0.55 (0.31, 0.97) | |||
Adjuvant | 16 | 0.45 (0.14, 1.43) | 0.34 (0.11, 1.02) | |||
Chemotherapy | No | 18 | 1.0 | 0.6 | 1.0 | 0.09 |
Primary | 4 | 3.35 (0.67, 16.71) | 0.48 (0.21, 1.1) | |||
Adjuvant | 6 | 1.24 (0.33, 4.64) | 1.29 (0.4, 4.14) | |||
AJCC | I and II | 10 | 1.0 | 0.021 | 1.0 | 0.27 |
III | 12 | 2.24 (1.13, 4.44) | 2.59 (0.74, 8.98) | |||
IV | 8 | 6.29 (1.2, 33.06) | 2.14 (0.57, 8.02) | |||
MSKCC | 0 and I | 5 | 1.0 | 0.11 | 1.0 | 0.14 |
II | 7 | 2.2 (0.84, 5.8) | 1.79 (0.82, 3.88) | |||
III and IV | 18 | 2.25 (0.29, 17.76) | 1.61 (0.45, 5.76) | |||
N1 or M1 | No | 22 | 1.0 | 0.11 | 1.0 | 0.67 |
Yes | 8 | 2.39 (0.81, 7.02) | 1.24 (0.47, 3.3) | |||
TNM | T1aN0M0-T1bN1M1 | 12 | 1.0 | 0.18 | 1.0 | 0.07 |
T2aN0M0-T2bN1M1 | 18 | 2.2 (0.7, 6.96) | 2.9 (0.93, 9.08) |