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. 2013 Jul 24;5(3):901–918. doi: 10.3390/cancers5030901

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

PHA-767491 does not affect BIM levels and causes caspase-independent MCL-1 downregulation. (A) KMS-18 and MM1S myeloma cells were incubated with 5 μM PHA-767491 for the indicated time. Protein extracts were prepared and analyzed by immunoblotting using the indicated antibodies; (B) KMS-18 and MM1S cells were incubated with 30 μM QVD-OPH for 30 min and then treated with 5 μM PHA767491for 6 h (KMS-18) or 9 h (MM1S). After incubation, protein extracts were prepared and analyzed by immunoblotting using the indicated antibodies. F-L and C in the PARP lane indicate full length and cleaved respectively. Percentage of AV⁺ cells is indicated at the bottom.