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. 2013 Jul 24;5(3):901–918. doi: 10.3390/cancers5030901

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

PHA-767491 induces apoptosis in KMS-18 and MM1S in co-culture with HS5 cells. KMS-18 (A) and MM1S (B) cells were cultured with (open square) or without (black circle) HS5-H2B-GFP cells for 2 h and then treated with different doses of PHA-767491 for a further 24 h. Apoptosis was assessed by AV staining. In parallel samples, KMS-18 (C) and MM1S (D) cultured with (gray bars) or without (white bars) HS5-H2B-GFP cells for 2 h, were treated with 5 nM bortezomib and apoptosis was analysed 24 h after treatment using AV staining. Data are presented as mean ± standard deviation of two independent repeats. The M in the x axes defines Molarity.