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. 2013 Jul 24;5(3):901–918. doi: 10.3390/cancers5030901

Figure 6.

Figure 6

Combination Analysis of PHA-767491 using Chou-Talalay Median-Effect Equation. MM1S cells were treated with PHA-767491 alone and in combination with Melphalan (Range 2 to 32 µM, A), Doxorubicin (Range 31 to 500 nM, B) or Bortezomib (Range 1.3 to 20 nM, C) in a non-constant ratio in a simultaneous fashion. Cell viability was examined by CellTiter Glo 48 h after drug treatment. Combination indices (CI) were calculated and the Log CI (circles) plotted in relation to the fraction of cells affected (Fa) at any given experimental point.