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. 2013 Sep 6;5(3):1140–1162. doi: 10.3390/cancers5031140

Figure 2.

Figure 2

Relationships between pro-angiogenic effects of leptin signaling and breast neoplasms, vascularization, and endothelial cell function. Many signaling pathways show the connections between regulation, expression and binding of leptin, IL-1, adhesion molecules (ICAM and integrins), Notch, VEGF/VEGFR and MMPs and, their impact on vessel development and endothelial cell function, which are essential for breast neoplasm development. The summary of the data processed by the Program Studio 9 [19] and specific molecular and cellular relationships can be found in the supplementary material. Notes: ITG (integrins); ITGB1 (integrin β1); IL-1A and B (IL-1α and β); Lep (leptin); ICAM (CD54, intercellular adhesion molecule 1).