Table 3. Pharmacokinetic Parameters.
| EGCg |
EGCgNIC·9H2O |
EGCgINM·5H2O |
EGCgINA·3H2O |
EGCgINA |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| mean | SD | mean | SD | mean | SD | mean | SD | mean | SD | |
| Tmax (min) | 7.50 | 2.74 | 20.00 | 10.95 | 30.00 | 0.00 | 30.00 | 24.49 | 160.00 | 61.97 |
| Cmax (ng/mL) | 341.50 | 247.10 | 188.33 | 106.26 | 125.95 | 67.91 | 347.17 | 236.92 | 167.40 | 84.66 |
| AUC(0–t) (min·ng/mL) | 39796.33 | 26318.73 | 22064.75 | 3410.81 | 22636.28 | 9177.62 | 54560.42 | 21954.28 | 41937.08 | 12165.97 |
| Frel | 1.00 | NA | 0.55 | NA | 0.57 | NA | 1.37 | NA | 1.05 | NA |
| HL_Lambda_z (min) | 249.35 | 60.73 | 341.71 | 212.97 | 263.74 | 68.31 | 352.61 | 79.85 | 350.83* | 195.13 |
*
Due to an insufficient number of data points in the elimination phase of the pharmacokinetic profile, Cmax was included in the Lambda_z calculation during the noncompartmental analysis in WinNonlin.