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Principal component analysis of HDAC3. (A) apo HDAC3, (B) IP4-bound HDAC3, (C) DAD-bound HDAC3, (D) IP4- and DAD-bound HDAC3, and (E) apo HDAC3R265P mutant dynamics are each projected onto PC1:PC2 space of the apo HDAC3WT12. A white cross in each panel indicates the projection of the HDAC3:IP4:DAD crystal structure (PDB ID: 4A6910).
