Table 1.

Demographic and Baseline Characteristics of All Study Participants at Baseline^a,b

Characteristic	NB32 (N = 25)
Age, mean (SD), y	47.2 (10.3)
Female, n (%)	25 (100)
Race, n (%)
White	23 (92.0)
Other	2 (8.0)
Weight, mean (SD), kg	95.5 (15.0)
Body mass index, mean (SD), kg/m2	34.8 (4.3)
Waist circumference, mean (SD), cm	102.5 (13.8)
MADRS total score, mean (SD)	24.0 (4.3)
IDS-SR total score, mean (SD)	43.2 (8.1)
Features of current major depressive disorder episode, n (%)
Atypical features	13 (52.0)
Melancholic features	12 (48.0)
Duration of current depressive episode, mean (SD), mo	10.2 (14.0)
Patients with ≥ 2 previous major depressive disorder episodes, n (%)	16 (64.0)
BES total weighted score, mean (SD)	28.4 (8.9)

^aAll enrolled patients.

^bScore ranges and clinical significance for the various questionnaires: MADRS (range, 0–60): ≤ 10 = remission, >10 = depression (the higher the number, the greater the degree of symptom severity); BES (range, 0–46): ≤ 17 = little or no problem, > 17 and < 27 = moderate problem, ≥ 27 = serious problem; IDS-SR (range, 0–84): 0–13 = no problem, 14–25 = mild, 26–38 = moderate, 39–48 = severe, 49–84 = very severe.

Abbreviations: BES = Binge Eating Scale, IDS-SR = Inventory of Depressive Symptomatology—Self-Report, MADRS = Montgomery-Asberg Depression Rating Scale, NB32 = naltrexone sustained-release 32 mg/bupropion sustained-release 360 mg.