Fig. 7.

The effects of CA on H6PDH and 11β-HSD1 in primary cultures of hepatocytes from db/db mice. a Primary hepatocytes were incubated with increased concentrations of the G6PT inhibitor CA (0– 200 µmol/l) for 48 h and H6PDH protein levels were determined by western blot analysis. b Hepatocytes were incubated with CA (150 µmol/l) for 48 h. H6pdh and 11β-Hsd1 mRNA were measured by real-time RT-PCR. Values are the mean±SEM from three separate culture preparations. **p<0.01 vs vehicle-treated hepatocytes. White bars, vehicle; black bars, CA