Figure 4. Effects of GCN2 deletion on ATF4 and CREB pathways in 5XFAD mice.

(A) Representative immunoblots of protein extracts from hippocampal homogenates of mice. (B) Immunoreactive bands were quantified and expressed as the percentage of 5XFAD control mice (n = 6–8). Note that GCN2^−/− deletion further increases ATF4 expression and accordingly reduces levels of phosphorylated CREB without affecting total CREB in 5XFAD mice. *p<0.05 vs. wild-type, ^# p<0.05 vs. 5XFAD. All data are presented as mean ± SEM.