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. 2013 Oct 11;8(10):e76986. doi: 10.1371/journal.pone.0076986

Table 5. Association between nadir CD4+ T cell count and the longitudinal rate of change in clinical periodontal measures adjusting for baseline level of periodontal pathogens.

Mean difference in rate of change in PPD per 12 months
Mean difference in rate of change in REC per 12 months
Model Exposure* Mean estimate (95%CI) p-value Mean estimate (95%CI) p-value
1 Nadir CD4 -0.04 (-1.39,1.32) 0.959 1.84 (0.23,3.45) 0.026
2 Nadir CD4 0.00 (-1.45,1.46) 0.996 1.89 (0.20,3.58) 0.029
3 Nadir CD4 0.01 (-1.47,1.50) 0.984a 1.83 (0.54,3.11) 0.006
3 Pg -0.58 (-1.68,0.51) 0.292a -1.51 (-2.61,-0.42) 0.008
4 Nadir CD4 -0.10 (-1.50,1.30) 0.885 1.89 (0.01,3.77) 0.049b
4 23s rDNA -1.55 (-6.12,3.02) 0.500 -0.20 (-6.93,6.54) 0.954b
5 Nadir CD4 0.26 (-1.28,1.81) 0.733 1.97 (0.27,3.68) 0.024
5 Td -0.92 (-2.24,0.39) 0.164 -0.27 (-1.55,1.01) 0.670
6 Nadir CD4 0.23 (-1.33,1.79) 0.766 1.89 (0.27,3.51) 0.023
6 Tf -0.80 (-2.72,1.12) 0.409 0.06 (-1.18,1.30) 0.921
Mean difference in rate of change in CAL per 12 months Mean difference in rate of change in BOP per 12 months
Model Exposure* Mean estimate (95%CI) p-value Mean estimate (95%CI) p-value
1 Nadir CD4 1.08 (-0.11,2.27) 0.075 0.12 (-1.92,2.16) 0.910
2 Nadir CD4 1.04 (-0.27,2.36) 0.117 0.06 (-1.96,2.08) 0.953
3 Nadir CD4 1.00 (-0.24,2.24) 0.113 0.08 (-2.12,2.29) 0.939a
3 Pg -0.83 (-2.22,0.56) 0.237 -1.67 (-3.17,-0.16) 0.030a
4 Nadir CD4 1.13 (-0.13,2.39) 0.078 -0.13 (-2.00,1.73) 0.888
4 23s rDNA 1.16 (-3.24,5.55) 0.600 -1.60 (-8.68,5.47) 0.652
5 Nadir CD4 1.03 (-0.41,2.46) 0.158 0.55 (-1.60,2.70) 0.610
5 Td 0.08 (-1.22,1.39) 0.899 -1.66 (-3.29,-0.02) 0.048
6 Nadir CD4 0.90 (-0.44,2.24) 0.182 0.70 (-1.39,2.79) 0.506c
6 Tf 0.52 (-0.69,1.73) 0.394 -1.95 (-4.01,0.12) 0.064c

Model 1: Unadjusted.

Models 2, 3, 4, 5 and 6: Adjusted for age and total pack-per-day years of cigarette smoking at baseline.

Nadir CD4, nadir CD4+ T cell count; PPD, periodontal probing depth, REC, gingival recession; CAL, clinical attachment level; BOP, bleeding on probing; Pg, Porphyromonas gingivalis; 23s rDNA, total 23s ribosomal DNA; Td, Treponema denticola; Tf, Tanneralla forsythia.

a

Interaction between baseline nadir CD4+ and log10 (Pg), p=0.027 for PPD and p=0.001 for BOP.

b

Interaction between baseline nadir CD4+ and log10(23s rDNA), p=0.031.

c

Interaction between baseline nadir CD4+ and log10 (Tf), p=0.006.

Exposure*: Nadir CD4+ T cell count is per 100 cells/µl increase; pathogens (Pg, 23s rDNA, Td and Tf) are per 1-log10 increase at baseline.