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. 2013 Oct 11;8(10):e76051. doi: 10.1371/journal.pone.0076051

Table 4. Predicted target genes for miRNAs that changed expression level at 7 d and 30 d after stimulation.

ID miRNA regulation Target gene p-value Log Ratio
7 d
miR-212-3p upregulated TLN2, talin 2 0.028 -0.173
miR-21-5p upregulated SESN1, sestrin 1 0.033 -0.175
BTG2, BTG family, member 2 0.004 -0.269
IL6R, interleukin 6 receptor 0.012 -0.276
SLC16A10, solute carrier family 16, member 10 (aromatic amino acid transporter) 0.002 -0.357
miR-124-3p downregulated ARPC1B, actin related protein 2/3 complex, subunit 1B 0.001 0.704
TMBIM1, transmembrane BAX inhibitor motif containing 1 0.000 0.641
GSN, gelsolin 0.032 0.566
NFATC1, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.003 0.534
PLP2, proteolipid protein 2 0.008 0.508
CYP1B1, cytochrome P450, family 1, subfamily B, polypeptide 1 0.009 0.485
CDK6, cyclin-dependent kinase 6 0.000 0.437
RBMS1, RNA binding motif, single stranded interacting protein 1 0.018 0.434
ELK3, ETS-domain protein (SRF accessory protein 2) 0.003 0.422
RHOG, ras homolog family member G 0.035 0.419
CTGF, connective tissue growth factor 0.011 0.369
BDNF, brain-derived neurotrophic factor 0.001 0.349
TJP2, tight junction protein 2 0.003 0.345
TLN1, talin 1 0.009 0.344
B4GALT1, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.002 0.321
PTTG1IP, pituitary tumor-transforming 1 interacting protein 0.027 0.307
MAGT1, magnesium transporter 1 0.019 0.306
CAV1, caveolin 1, caveolae protein 0.028 0.280
RASSF5, Ras association (RalGDS/AF-6) domain family member 5 0.006 0.273
FAM129B, family with sequence similarity 129, member B 0.036 0.271
RBM47, RNA binding motif protein 47 0.012 0.256
LMNB1, lamin B1 0.011 0.253
PLSCR3, phospholipid scramblase 3 0.045 0.240
PTBP1, polypyrimidine tract binding protein 1 0.022 0.236
CDK4, cyclin-dependent kinase 4 0.009 0.208
ATP6V0E1, ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.015 0.200
RELA, v-rel reticuloendotheliosis viral oncogene homolog A 0.038 0.172
DNM2, dynamin 2 0.047 0.161
MAD2L2, MAD2 mitotic arrest deficient-like 2 0.050 0.151
ELF4, E74-like factor 4 (ets domain transcription factor) 0.005 0.130
ALDH9A1, aldehyde dehydrogenase 9 family, member A1 0.042 0.127
miR-301a-3p downregulated MAFB, v-maf musculoaponeurotic fibrosarcoma oncogene homolog B 0.001 0.576
CSF1, colony stimulating factor 1 0.037 0.252
miR-30d-5p downregulated RBMS1, RNA binding motif, single stranded interacting protein 1 0.018 0.434
CBFB, core-binding factor, beta subunit 0.044 0.403
CTGF, connective tissue growth factor 0.011 0.369
MET, met proto-oncogene (hepatocyte growth factor receptor) 0.003 0.283
TP53, tumor protein p53 0.046 0.216
RUNX2, runt-related transcription factor 2 0.014 0.207
SLC4A7, solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.043 0.189
miR-328a-3p downregulated CD44, CD44 molecule 0.001 0.713
miR-33-5p downregulated ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1 0.003 0.634
miR-92b-3p downregulated ENPP6, ectonucleotide pyrophosphatase/phosphodiesterase 6 0.003 0.846
IKZF1, IKAROS family zinc finger 1 0.000 0.521
CDKN1A, cyclin-dependent kinase inhibitor 1A 0.013 0.331
ITGA5, integrin, Ralpha 5 0.033 0.170
30 d
miR-146a-5p upregulated NFIX, nuclear factor I/X (CCAAT-binding transcription factor) 0.033 -0.090
PA2G4, Proliferation-Associated Protein 2G 0.030 -0.113
METTL7A, methyltransferase like 7A 0.014 -0.166
IL1RAP, interleukin 1 receptor accessory protein 0.035 -0.170
miR-21-5p upregulated CDC25A, cell division cycle 25A 0.011 -0.137
SOCS5, suppressor of cytokine signaling 5 0.007 -0.300
IL6R, interleukin 6 receptor 0.018 -0.318
SLC16A10, solute carrier family 16, member 10 (aromatic amino acid transporter) 0.007 -0.354
miR-23a-3p upregulated SMAD5, SMAD family member 5 0.013 -0.120
IL6R, interleukin 6 receptor 0.018 -0.318
miR-34a-5p upregulated DLL1, delta-like 1 0.014 -0.188
VEGFA, vascular endothelial growth factor A 0.039 -0.200
miR-29b-3p downregulated ZFP36L1, ZFP36 ring finger protein-like 1 0.028 0.287
SPARC, secreted protein, acidic, cysteine-rich (osteonectin) 0.012 0.260
COL1A2, collagen, type I, alpha 2 0.032 0.186
miR-30e-5p downregulated CPNE8, copine VIII 0.028 0.372
ADPGK, ADP-dependent glucokinase 0.005 0.238
SLC7A11, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.041 0.230
TP53, tumor protein p53 0.045 0.182
TMED10, transmembrane emp24-like trafficking protein 10 (yeast) 0.020 0.177
MPDU1, mannose-P-dolichol utilization defect 1 0.044 0.144