Figure 5. Deletion of fgl2 enhances anti-viral B cell responses following LCMV WE infection.

A) The numbers of plasma cells (CD138⁺CD45R^lowCD19^low) in the spleen of LCMV-infected fgl2^+/+ or fgl2 ^−/− mice were evaluated in uninfected mice (day 0) and day 8 pi by flow cytometry. Data represent the mean±SEM of 5 mice per group and are representative of 2 independent experiments. B) By ELISA, total LCMV-specific IgG antibody titers were measured in the plasma of infected mice on different time points post-infection. Data represents the mean±SEM of 5 mice infected and sacrificed at each time-point. C) Neutralizing antibody titers were assessed in the plasma of infected mice on different time points post-infection using a standard plaque reduction assay. The graph shows the dilution of plasma required for 50% plaque reduction. Data represents the mean±SEM of 3 mice infected and sacrificed at each time-point. Statistical significance was assessed using a one-way ANOVA; * P<0.05.