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. 2013 Oct 11;8(10):e76667. doi: 10.1371/journal.pone.0076667

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Representative counter plot of Annexin V v.s. 7-ADD staining for apoptotic cells measured by flow cytometric analysis upon siRNA PAR-2 knockdown in OE33 cells; (B) Apoptosis is expressed as a percentage of early apoptotic cells (right lower quadrant) in total cell population for OE19, OE33 and FLO1. (C) Effect of siRNA PAR-2 knockdown on cell viability measured by MTT assay in OE19 and OE33 cells. (D) PAR-2 inactivation with its antagonist ENMD or anti-PAR-2 antibody SAM -11 decreased cell viability in comparing with untreated control cells in OE19 and OE33 cell.