Table 4. Factors associated with unfavorable treatment outcomes among smear positive retreatment tuberculosis patients registered in three districts of Andhra Pradesh, India, April 2011 to March 2012 (N=1077).
| Characteristic | Unfavorable outcomes | Favorable outcomes | Unadjusted RR (95% CI) | Adjusted RR (95% CI) |
|---|---|---|---|---|
| N (%) | N (%) | |||
| Total | 351(32.6) | 726 (67.4) | ||
| INH resistance | ||||
| Yes | 64 (44.4) | 80 (55.6) | 1.44 (1.18-1.78) | 1.46(1.19-1.78) |
| No | 287 (30.8) | 646 (69.2) | Reference | Reference |
| Sex | ||||
| Male | 276 (35.1) | 510 (64.9) | 1.36 (1.10-1.69) | 1.36(1.09-1.68) |
| Female | 75 (25.8) | 216 (74.2) | Reference | Reference |
| Age | ||||
| <40 years | 196 (31.1) | 435 (68.9) | Reference | |
| >40 years | 155 (34.8) | 291 (65.2) | 1.12(0.94-1.33) | |
| Type | ||||
| Relapse | 158 (28.5) | 397 (71.5) | Reference | Reference |
| TAD | 142 (34.1) | 275 (65.9) | 1.20 (0.99-1.44) | 1.18(0.98-1.42) |
| Failure | 51 (48.6) | 54 (51.4) | 1.71(1.35-2.16) | 1.62(1.28-2.04) |
| HIV status | ||||
| Negative | 310 (31.5) | 675 (68.5) | Reference | Reference |
| Positive | 29 (42.0) | 40 (58.0) | 1.34 (1.00-1.79) | 1.34 (1.00-1.77) |
| Unknown | 12 (52.2) | 11 (47.8) | 1.66 (1.11-2.48) | 1.68 (1.13-2.51) |
| ART | ||||
| Received | 22 (36.2) | 37 (63.8) | Reference | |
| Not received | 7 (70.0) | 3 (30.0) | 1.93 (1.14-3.29)# |
ART- anti retroviral therapy; TAD-treatment after default; HIV- Human immunodeficiency virus; INH-isoniazid; RR-Relative Risk; CI-Confidence Interval Variables with RR and 95% CI in bold are statistically significant (P value < 0.05)
Unfavorable outcomes-died, default, transferred out and failure
Favorable outcomes-cured and treatment completed
# Fischer exact test