Table 4. Single-point association analysis of SNPs in NLRP6/AVR and ADM with hypertension.
| Gene (chr) | SNP | Position | Pa | OR (95% c.i.) | Pb | OR (95% c.i.) | Pc | OR (95% c.i.) |
|---|---|---|---|---|---|---|---|---|
| NLRP6/AVR (11) | rs7948797 | 269,856 | 0.056 | 0.73 (0.57-0.94) | 0.029 | 0.63 (0.45-0.88) | 0.845 | 0.86 (0.60-1.24) |
| rs7937440 | 272,274 | 0.032 | 0.76 (0.60-0.95) | 0.100 | 0.73 (0.53-1.00) | 0.585 | 0.79 (0.57-1.09) | |
| rs11246048 | 278,039 | 0.254 | 1.17 (0.92-1.48) | 0.180 | 1.29 (0.92-1.81) | 0.694 | 1.07 (0.77-1.49) | |
| rs4758635 | 283,928 | 0.191 | 0.86 (0.68-1.08) | 0.150 | 0.79 (0.57-1.09) | 0.838 | 0.92 (0.67-1.28) | |
| ADM (11) | rs4399321 | 10,323,478 | 0.104 | 1.23 (0.96-1.58) | 0.142 | 1.31 (0.91-1.87) | 0.410 | 1.16 (0.81-1.66) |
| rs4444073 | 10,331,664 | 0.006 | 1.44 (1.13-1.84) | 0.013 | 1.62 (1.14-2.29) | 0.286 | 1.29 (0.92-1.81) |
NLRP6, NLR family, pyrin domain containing 6; AVR, angiotensin-vasopressin receptor; ADM, adrenomedullin; P a, P in males + females; P b, P in males; P c, P in females. OR, odds ratio; c.i., confidence interval. Association analysis was performed with the HelixTree Genetic Analysis Software using Basic Allelic Tests: D vs d as genetic model. P, Chi-Squared FDR (Chi-squared P adjusted for multiple comparisons with False Discovery Rate procedure). Significant results (P < 0.05) are shown in boldface type.