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. Author manuscript; available in PMC: 2014 Sep 28.
Published in final edited form as: Org Biomol Chem. 2013 Sep 28;11(36):6036–6046. doi: 10.1039/c3ob40900g

Table 5.

Array of 4,5,6,7-tetrahydropyrazolo[1,5-a]-pyrazine-4-one tetrazole derivatives 24

graphic file with name nihms515809t59.jpg
R1 R2 Product Ugi
(%)		 Final Steps*
(%)
graphic file with name nihms515809t60.jpg graphic file with name nihms515809t61.jpg 24a 74 51
graphic file with name nihms515809t62.jpg graphic file with name nihms515809t63.jpg 24b 73 57
graphic file with name nihms515809t64.jpg graphic file with name nihms515809t65.jpg 24c 67 78
graphic file with name nihms515809t66.jpg graphic file with name nihms515809t67.jpg 24d 51 72
graphic file with name nihms515809t68.jpg graphic file with name nihms515809t69.jpg 24e 42 55
*

Basic hydrolysis and SOCl2 activation