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. Author manuscript; available in PMC: 2014 Nov 10.
Published in final edited form as: J Control Release. 2013 May 25;171(3):330–338. doi: 10.1016/j.jconrel.2013.05.013

Figure 1. Design of ELP nanoparticles that carry anti-proliferative drugs-- decoration with protein drug receptors minimally influences assembly. a.

Figure 1

Schematic showing high-avidity interaction between a drug and its cognate human target decorated at the nanoparticle surface, while the nanoparticle core may facilitate lower-avidity drug affinity. b. SDS-PAGE of ELP library stained with copper chloride (Table 1). c. Representative optical density (I48S48) used to determine ELP-mediated assembly as a function of temperature and concentration. At 25 μM, the CMT is 27 °C, while a bulk phase transition occurs at 85 °C. d. DLS analysis of I48S48 and F24S24. Above CMT (27°C for 25 μM), I48S48 forms stable micelles with a hydrodynamic radius of 24 nm. For F24S24, nanoparticles have already assembled below 4°C. (Mean ± SD, N=3) e. DLS analysis of SI and FSI. Above their CMT, Both SI and FSI form stable nanoparticles with similar hydrodynamic radii of 24 nm (Mean ± SD, N=3)