Figure 4. Morphology of ELP nanoparticles is minimally influenced by fusion of FKBP or encapsulation of Rapa.
a, b. Cryo-TEM imaging of ELP nanoparticles with and without the FKBP domain. a. The average radius of FSI is 18.5 ± 1.3 nm. b. The average radius of SI nanoparticles is 15.0 ± 2.3 nm. Mean ± SD (n = 10). Bar length = 200nm. c. A comparison of FSI nanoparticle radius determined using TEM and DLS before and after Rapa encapsulation suggests that presentation and loading of the FKBP domain minimally affects nanoparticle morphology. Mean ± SD (n = 10). (**p=0.005 and *p=0.05)