Skip to main content
. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Fitoterapia. 2013 Jul 10;0:160–184. doi: 10.1016/j.fitote.2013.07.003

Table 6.

Glabridin Effects on Intracellular Oxidative Burst and Biological Responses

Intracellular Antioxidant Activity Response1 Biological Effects2 Ref.
Reduction of intracellular ROS in Raw 264.7 macrophages Inhibition of NF-κB/Rel activation Anti-inflammatory [68]
Suppression of MPO activity Reduction of tissue damages
Inhibition of PKC and induction of SOD, CAT and PON2
Protection of mitochondrial respiratory enzymes 		Inhibition of cellular mediated LDL oxidation Anti-atherogenic [48]
[80]
Protection of mitochondrial respiratory Enzymes against peroxidation. Increase PI3K activity and CREB phosphorylation Anti-osteoporotic

Promotion of bone recovery 		[100]
[98]
[97]
Up-regulation of antioxidant enzymes
SOD1 and GPX4 in MC3T3-E1
Osteoblastic cells		 Up-regulation of PI3K and AKT2
Reduction of intracellular ROS induced By UVB radiations in Normal Human Keratinocytes (NHK) Prevention of DNA damages Chemo-preventive [118]
Increase of antioxidative markers SOD And glutathione in cerebral tissue of MCAO rats
Decrease of MDA level		 Reduction of cerebral ischemia Neuroprotective [84]
1

Response: Cellular response directly linked to intracellular antioxidant activity.

2

Biological Effect: General effect observed resulting from the cellular response.