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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: ACS Synth Biol. 2013 Jun 11;2(11):629–634. doi: 10.1021/sb400048b

Figure 1.

Figure 1

Comparison of conserved gene clusters across different dermatophyte and pathogenic fungi. All of the fungi shown contain a conserved core PKS gene cassette that consists of a nonreducing polyketide synthase (NR-PKS), β-lactamase thioesterase (TE), flavin-dependent monooxygenase (FMO) and polycyclic prenyltransferase (pcPT). A fungal transcription factor (TF) is also found immediately adjacent to the core PKS genes. In dermatophytes, additional genes are also found adjacent to the core PKS gene cassette, among which many are conserved across different fungi. Some of the genes include dioxygenase (DO), hypothetical protein (HP), amino acid racemase (R), major facilitator superfamily transporters (MFS) and alcohol dehydrogenase (ADH). In A. otae, an additional C6 transcriptional factor (TF2) is adjacent to the core PKS gene cassette.