Fig. 2.

Dietary AGE restriction restores SIRT1 and improves inflammatory and oxidative stress markers in healthy subjects. After 4 months of AGE-restricted diet (closed bars) or regular diet (open bars), changes in circulating CML, MG and 8-isoprostane, and in MNC TNFα protein and SIRT1 mRNA (by RT-PCR) levels are shown as percentage from baseline (mean ± SEM). *p < 0.050 refers to statistical significance in percent change between baseline and end of study between both groups