Table 2.
Results from Illumina Beadchip analysis: differential expression in the VMB following 100 days on a low iron diet. These are changes that occurred across the six strains. Highlighted in gray are genes with a known role in heme biosynthesis or function. LR=Log2 ratio of ID/CN, Q=FDR.
| Gene | Probe ID | Location Chr: Mb | eQTL Chr: Mb | Log Ratio | Q-Value |
|---|---|---|---|---|---|
| Erythrocyte membrane protein band 3, Diego blood group | |||||
| Slc4a1 | ILMN_1227675 | 11: 102.2 | 14*: 46.7* | 1.27 | 0.0000 |
| Aminolevulinic acid synthase 2, erythroid | |||||
| Alas2 | ILMN_2675874 | X: 147.0 | --- | 1.04 | 0.0000 |
| Hemoglobin, beta adult chain | |||||
| Hbb-b1 | ILMN_1239117 | 7: 103.7 | 14: 67.1 | 0.81 | 0.0168 |
| Apolipoprotein L 11b | |||||
| Apol11b | ILMN_1252157 | 15: 77.5 | 13: 41.5 | 0.98 | 0.0000 |
| Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | |||||
| Cxcl12 | ILMN_2658908 | 6: 117.1 | --- | 0.75 | 0.0000 |
| Radical S-adenosyl methionine domain containing 2 | |||||
| Rsad2 | ILMN_1225204 | 12: 27.1 | 15: 21.7 | 0.66 | 0.0018 |
| Transferrin receptor | |||||
| Tfrc | ILMN_2860804 | 16: 32.6 | --- | 0.58 | 0.0001 |
| Glycophorin A | |||||
| Gypa | ILMN_2696696 | 8: 83.0 | 2: 15.3 | 0.59 | 0.0001 |
| Alkaline ceramidase 2 | |||||
| Asah3l (Acer2) | ILMN_2629112 | 4: 86.6 | 4**: 88.0** | 0.58 | 0.0001 |
| Alpha hemoglobin stabilizing protein | |||||
| Eraf (Ahsp) | ILMN_2619200 | Unknown | --- | 0.45 | 0.0168 |
| 8430408G22Rik | |||||
| Fseg (Depp) | ILMN_2894211 | 6: 116.6 | --- | 0.45 | 0.0000 |
| E2F transcription factor 2 | |||||
| E2f2 | ILMN_2673776 | 4: 135.7 | 7: 125.8 | 0.35 | 0.0168 |
| Ubiquitin-conjugating enzyme E2L 6 | |||||
| Ube2l6 | ILMN_2431619 | 0.25 | 0.0473 | ||