Table 2.
Associations of each lung function measure with clinical characteristics at the same study visit, from a mixed effects model
| Observations (Subjects) | FEV0.5 (ml) | FEF75 (ml/s) | Observations (Subjects) | FRC (ml) | |
|---|---|---|---|---|---|
|
| |||||
| Clinical Characteristics | N (n) | Estimate (95% CI) | Estimate (95% CI) | N (n) | Estimate (95% CI) |
|
| |||||
| Continuous predictors | |||||
|
| |||||
| Weight Percentile | 246 (90) | 0.02 (-0.39, 0.42) | -0.23 (-1.09, 0.63) | 303 (96) | -0.15 (-0.50, 0.20) |
|
| |||||
| Brasfield Score | 132 (87) | -4.62 (-11.33, 2.09) | -9.49 (-24.67, 5.68) | 154 (92) | -5.96 (-12.45, 0.53) |
|
| |||||
| Wisconsin Score | 132 (87) | 2.81 (-1.85, 7.48) | 0.93 (-9.67, 11.53) | 154 (92) | 4.62 (0.66, 8.59) |
|
| |||||
| Respiratory Rate | 246 (90) | -0.70 (-1.53, 0.13) | -1.21 (-2.93, 0.52) | 303 (96) | 0.61 (-0.04, 1.26) |
|
| |||||
| Oximetry | 246 (90) | -0.99 (-5.67, 3.70) | -0.17 (-9.96, 9.63) | 303 (96) | -0.75 (-1.56, 0.07) |
|
| |||||
| Categorical predictors | |||||
|
| |||||
| Cigarette smoke exposure1 | 246 (90) | -13.0 (-44.1, 18.1) | -27.4 (-96.2, 41.4) | 303 (96) | 24.4 (-10.3, 59.0) |
|
| |||||
| P. aeruginosa isolated from most recent culture | 194 (89) | -19.2 (-42.2, 3.9) | -37.9 (-85.8, 10.0) | 235 (96) | 17.3 (-1.3, 36.0) |
|
| |||||
| S. aureus isolated from most recent culture | 194 (89) | 6.9 (-10.7, 24.5) | 4.4 (-32.6, 41.4) | 235 (96) | 19.3 (5.1, 33.4) |
|
| |||||
| Parent-reported cough2 | 245 (90) | -12.6 (-26.8, 1.7) | -34.6 (-64.2, -5.1) | 302 (96) | -9.4 (-20.6, 1.9) |
|
| |||||
| CFTR functional class3 | 246 (90) | 303 (96) | |||
| Residual function | 32.8 (-15.6, 81.2) | 35.8 (-70.4, 142.0) | 14.9 (-34.6, 64.4) | ||
| Unclassified | 4.7 (-22.5, 31.8) | -15.9 (-76.0, 44.2) | 2.0 (-26.6, 30.5) | ||
For continuous measures, estimated mean change in iPFT measure for every one unit change in clinical measure. For categorical measures, estimated mean difference in iPFT measure between categories. Mixed effects models with a random intercept were employed; all models were adjusted for length, age and gender. Significant results are presented in bold.
1
Collected at baseline visit only
2
Any cough vs. none