Figure 1. Homeostatic regulation of excitatory synapses in L2/3 of V1 depends on the mode of visual deprivation.

Manipulations that trigger homeostatic scaling up of mEPSC amplitude are the ones that prevent visually driven activity (DE or EN). The residual visual activity through the eye lids prevent homeostatic synaptic plasticity, but instead either result in no change in the average mEPSC or produce synaptic depression, likely via a LTD-type of mechanism.