Table 1.

Distribution of global health R&D funding across neglected diseases

Disease	Global R&D funding 2011 (million US$)	Global BoD (million DALYs)	Global R&D funding in US$/global DALY
HIV	1,117	81.5	13.7
Malaria	596	82.7	7.2
Tuberculosis	584	49.4	11.8
Dengue	249	0.8	301.7
Diarrhoeal diseases	169	89.5	2.0
Kinetoplastids	142	4.4	32.0
Bacterial pneumonia and meningitis	107	68.0–104.9a	1.0–1.6
Helminths (worms and flukes)	90	12.3	7.3
Salmonella infections	48	17.1	2.8
Trachoma	10	0.3	31.1
Leprosy	8	0.006	1400.9
Buruli ulcer	6	NAb	–
Rheumatic fever	1	10.1	0.1

Notes: Table is based on Table 2 from the G-FINDER report 2012, which reports on global R&D funding for 31 neglected diseases (12). ‘Neglected diseases’ are defined in this report as diseases that disproportionally affect people in developing countries, for which there is a need for new products, and for which there is market failure. The list of 31 diseases includes HIV, tuberculosis and malaria, and thus adheres to a different definition of neglected diseases than WHO (24). Burden of disease (BoD) data are from the Global Burden of Disease (GBD) study 2010 (25). DALYs=disability-adjusted life years.

^aGlobal BoD for bacterial pneumonia and meningitis is displayed as a range because ‘other LRIs’ and ‘other meningitis’ in the GBD study 2010 were not sub-specified into viral or bacterial pathogens. The lower limit represents the BoD without the ‘other’ categories, while the upper limit includes the ‘other categories’.

^bGlobal BoD data for buruli ulcer were not available.