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Sustained CNS viral replication in IL-21R−/− mice is not associated with accelerated demyelination, but increases mortality. (A) Representative demyelination in cross sections of spinal cords at day 14 p.i. identified with LFB. WT and IL-21R−/− mice show similar extent of demyelination. Magnification bar = 200 μm. (B) WT and IL-21R−/− infected mice were monitored daily for clinical symptoms. (C) Survival of infected WT and IL-21R−/− mice.
