Table 2. Lipid SNPs with evidence of menopausal status as a modifier in females of European-descent.
Single-SNP tests of association were performed within each age group and in the combined dataset. Beta and standard error (SE), p-value (P), and sample size (N) are given for each association. The beta estimate is per additional copy of the coded allele (CA). Tests of heterogeneity were performed between the two age strata and the resulting p-value (Phet) and I2 index are also reported. Only results where Phet<0.05 are reported. Coded allele frequency (CAF).
| SNP | Gene | Lipid Trait |
CA (CAF) |
Pre-Menopausal | Post-Menopausal | All Females | Phet | I2 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta (SE) |
P | N | Beta (SE) |
P | N | Beta (SE) |
P | N | ||||||
| rs2197089 | LPL | HDL | T (0.54) |
0.29 (0.36) |
0.41 | 3291 | 1.20 (0.29) |
3.17E- 05 |
8123 | 0.84 (0.24) |
1.73E- 04 |
11414 | 0.049 | 74.3 |
| rs3764261 | CETP | HDL | T (0.33) |
4.48 (0.37) |
1.97E- 33 |
3201 | 3.41 (0.38) |
1.09E- 19 |
4677 | 3.95 (0.26) |
1.58E- 50 |
7878 | 0.042 | 75.7 |
| rs4803750 | BCL3 | LDL | A (0.93) |
13.08 (2.52) |
2.04E- 07 |
1473 | 5.28 (1.65) |
1.36E- 03 |
4536 | 7.62 (0.38) |
3.32E- 08 |
6009 | 9.42E-03 | 85.2 |
| rs9989419 | CETP | LDL | A (0.39) |
−0.84 (0.83) |
0.32 | 3041 | 2.36 (0.73) |
1.25E- 03 |
5239 | 0.97 (0.55) |
0.08 | 8280 | 3.98E-03 | 87.9 |
| rs1883025 | ABCA1 | TG | T (0.26) |
−0.05 (0.02) |
1.73E- 03 |
1111 | −0.01 (0.02) |
0.69 | 1166 | −0.03 (0.01) |
0.02 | 2277 | 0.038 | 76.8 |
| rs562338 | APOB | TG | T (0.20) |
0.02 (0.01) |
0.27 | 3192 | −0.03 (0.01) |
0.02 | 7084 | −0.01 (0.01) |
0.24 | 10276 | 0.025 | 80.0 |
| rs754523 | APOB | TG | T (0.69) |
0.02 (0.01) |
0.13 | 3176 | −0.02 (0.01) |
0.07 | 4777 | −0.003 (0.01) |
0.67 | 7953 | 0.021 | 81.3 |