Table 1.

Comparison of SCAF to RDoC Domains

SCAF Domain48	Relevant RDoC Subdomains54	Exemplar Brain Regions	Example Behaviors
1. Acquiring social-emotional values	Reward learning, habit learning, declarative memory, attachment formation	Amygdala, ventral striatum, orbitofrontal cortex, medial temporal lobe	Fear conditioning, reward learning, explicit memory for social stimuli
2. Recognition of stimuli with social-emotional value	Reception of facial communication, reception of nonfacial communication, animacy perception	Amygdala, striatum, insula, orbitofrontal cortex, fusiform face area, extrastriate body area, superior temporal sulcus/gyrus	Perception of nonverbal social cues, including faces and their parts, bodies, tone of voice and perception of biological motion
3. Low-level mental state inference	Action identification	Parietal and prefrontal motor regions (ie, mirror neuron system)	Identify what action someone is performing
4. High-level mental state inference	Understanding mental states, self-knowledge	Medial prefrontal cortex, precuneus, temporal pole, temporal parietal junction	Tests of theory of mind, attributions about mental states or traits for self or other (including judgments of self- reference), judgments about why someone is performing an action
5. Context-appropriate regulation	Any subdomain related to perceiving social cues or exhibiting an affective reaction plus the cognitive control domain and all its subdomains	Lateral, medial, and orbital prefrontal cortex	Cognitive reappraisal, extinction, reversal learning

Note: RDoC, Research Domain Criteria; SCAF, Social Cognition and Functioning in Schizophrenia.