Table 4.
Summary of Evidence for Target of 2nd Generation GSMs
| GSM used in study | Method | Target | Ref |
|---|---|---|---|
| GSM-1 (acid GSM) | Biotinylated or clickable photoprobes label PS1-NTF in cell membranes or with recombinant PS proteins. | PS1-NTF PS1-FL PS1-ΔE9 without APP |
(123) (154) |
| BB25 AR80 (acid GSM) |
Biotinylated photoprobes label PS1-NTF in cell membranes and live cells | PS1-NTF | (179) |
| GSM-97555 (imidazole GSM) | Pull-down with GSM immobilized Affigel matrix | Pen-2≫ PS1-NTF > PS1-CTF |
(127) |
| RO-57 (imidazole GSM) | Biotinylated photoprobes label PS-NTF in cell membranes | PS1-NTF PS2-NTF |
(136) |
| E2012 (imidazole GSM) | Clickable photoprobes label PS1-NTF in cell membranes, recombinant PS proteins, and live cells and neurons | PS1-NTF PS1-ΔE9 without APP |
(180) |