Table 1. Patient Characteristics.

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7	Patient 8	Patient 9
Clinical Diagnosis	PSP	PSP, elements of bvFTD	bvFTD	nfvPPA	nfvPPA, elements of PSP	CBS	CBS, elements of nfvPPA	AD	AD
Age at Onset/Sex	48F	60 F	67 M	69 F	53 M	64 M	62 M	75 M	79 F
Clinical Symptoms/Signs at Presentation	Diplopia Apathy Memory Word finding Falls Pseudobulbar affect Masked facies reduced vertical saccade velocity and increased latency LUE dystonia L>R parkinsonism	personality changes falls gait change executive symptoms reduced vertical saccade velocity hypomimia dysarthria axial rigidity L>R parkinsonism	Apathy Hyperorality Repetitive movement Hypomimia Axial rigidity Diminished L arm swing BUE tremor	Naming difficulty Stuttering Apraxia of speech Reduced blinking	Word-finding Reading language comprehension disinhibition Apraxia of speech LUE postural tremor Arms dystonic	Memory problem solving apraxia L>R Increased saccade latency Limb myoclonus LUE dystonia and tremor L Babinski	Diplopia visual misperceptions Word finding executive symptoms memory hypomimia apraxia of speech Increased saccade latency Axial/bilateral UE rigidity LUE dystonia and weakness	Memory Suspicious LUE cogwheel rigidity and postural tremor Right hand tremor when writing	Memory BUE tremor
Family History	Brother: OCD/schizophrenia Brother: epilepsy	Mother, 5 maternal aunts: psychiatric degenerative disease	Maternal aunt and uncle: dementia	Brother: ALS	Brother: stuttering Paternal uncle and maternal grandmother: PD Paternal: alcoholism, psychiatric disease	Father: dementia	Brother: dementia (multiple concussions)	Mother: died at 30 Father died at 45 Brother died at 65 from myocardial infarction.	Paternal aunt: dementia
CSF laboratory tests (pg/mL)*	-	Abeta42: 383 Total tau: 287 Phospho-tau: 41 ATI: 0.66 Inconclusive for AD	-	-	-	-	Abeta 42: 139 Total tau: 887 Phospho-tau: 89 ATI: 0.11 Consistent w/AD	-	-
Genetic Testing(MAPT/APOE)**	MAPT H1/H1 Apo E3/E3	MAPT H1/H2 Apo E3/E3	MAPT H1/H1 Apo E2/E3	MAPT H1/H2 Apo E3/E3	MAPT H1/H1 Apo E3/E3	MAPT H1/H1 Apo E3/E3	MAPT H1/H1 Apo E4/E2	MAPT H1/H1 Apo E3/E3	MAPT H1/H1 Apo E3/E3

Abbreviations: AD=Alzheimer's disease. ApoE=apolipoprotein E. ATI=amyloid-tau index. BUE=bilateral upper extremity. bvFTD=behavioral variant frontotemporal dementia. CBS=corticobasal syndrome. CSF= cerebrospinal fluid. DTR=deep tendon reflexes. MAPT=microtubule associated protein tau. L=left. LUE=left upper extremity. LLE=left lower extremity. nfvPPA= nonfluent variant primary progressive aphasia. OCD=obsessive-compulsive disorder. PD=Parkinson's disease. PSP=progressive supranuclear palsy. R=right.

^*normal reference ranges are: Phospho-tau < 61 pg/mL, ATI= Abeta42/(240 +1.18 total tau). ATI < 1 is consistent with AD. ATI > 1 for non-AD.

^**All 9 subjects tested negative for MAPT, GRN, and C9ORF72 mutations.