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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Menopause. 2014 Jan;21(1):10.1097/GME.0b013e31829337a4. doi: 10.1097/GME.0b013e31829337a4

Table 3.

Comparisons and sample sizes for MsFLASH clinical trials

Trial Intervention group Comparison group Effect
size*
01 Escitalopram n=100 Placebo n=100 2.1
02 Exercise and (Omega-3/Placebo) n=112 Usual activity and (Omega-3/Placebo) n=150 2.0
Yoga and (Omega-3/Placebo) n=112 Usual activity and (Omega-3/Placebo) n=150 2.0
Omega-3 and (Exercise/Yoga/Usual) n=187 Placebo and (Exercise/Yoga/Usual) n=187 1.6
03 Venlafaxine n=87 Placebo n=130 2.1
Estradiol n=87 Placebo n=130 2.1
*

Measured as difference between groups in VMS frequency per day change from baseline to follow-up, assuming a standard deviation of 4.0 VMS per day. Sample size calculations were based on t-tests with power of 90% and 2-sided alpha = 0.025.