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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Menopause. 2014 Jan;21(1):10.1097/GME.0b013e31829337a4. doi: 10.1097/GME.0b013e31829337a4

Table 4.

Statistical power to detect a treatment difference in vasomotor symptom frequency, based on 5,000 Monte Carlo simulations per correlation level

Correlation1 Post-treatment2 Percent change
from baseline3 		50% change
from baseline4
0.3 0.91 0.81 0.72
0.5 0.95 0.92 0.81
0.7 0.99 0.99 0.91

VMS change from baseline to follow-up values assumed to follow a normal distribution; sample size of 90 per treatment group; analysis includes one follow-up time point measure.

1

correlation between baseline and post-treatment measurements

2

models post-treatment outcome as a continuous outcome, adjusted for the baseline measure

3

models percent change from baseline as a continuous outcome

4

models proportion with at least a 50% decrease in VMS symptoms