Figure 2.

Influence of hyperglycemia and pancreatitis on RAGE proteins in the pancreas 33 hours after the first cerulein administration. Pancreas of control (sham), cerulein (Cer), streptozotocin (STZ) or streptozotocin plus cerulein (STZ+Cer) treated mice were analyzed by Western blots using the sc-8230 anti-RAGE antibody (A) and an anti-β-tubulin antibody as control (B). Densitometry of Western blots compared the expression of RAGE 1-6 (C-H) and revealed a significant reduction of RAGE 5 and 6 in STZ+cerulein treated mice (G and H). Values denote median and interquartile range. *p≤0.038 versus cerulein treated mice using Kruskal-Wallis One Way Analysis of Variance on Ranks followed by Tukey Test for all pairwise comparisons.