Table 3.
Correlation between clinicopathologic factors with expression of autophagy-related proteins in epithelial component*
| Parameters | Nuclear beclin-1 | Cytoplasmic beclin-1 | LC3A | LC3B | P62 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||||
| (-) n=111 (%) | (+) n=79 (%) | p-value | (-) n=101 (%) | (+) n=89 (%) | p-value | (-) n=185 (%) | (+) n=5 (%) | p-value | (-) n=34 (%) | (+) n=156 (%) | p-value | (-) n=161 (%) | (+) n=29 (%) | p-value | |
| Stromal cellularity | 1.065 | 4.155 | 1.865 | 2.385 | 1.470 | ||||||||||
| Mild | 78 (70.3) | 45 (57.0) | 66 (65.3) | 57 (64.0) | 121 (65.4) | 2 (40.0) | 25 (73.5) | 98 (62.8) | 107 (66.5) | 16 (55.2) | |||||
| Moderate | 28 (25.2) | 33 (41.8) | 32 (31.7) | 29 (32.6) | 58 (31.4) | 3 (60.0) | 7 (20.6) | 54 (34.8) | 49 (30.4) | 12 (41.4) | |||||
| Marked | 5 (4.5) | 1 (1.3) | 3 (3.0) | 3 (3.4) | 6 (3.2) | 0 (0.0) | 2 (5.9) | 4 (2.6) | 5 (3.1) | 1 (3.4) | |||||
| Stromal atypia | 0.220 | 3.620 | 4.315 | 2.160 | 0.230 | ||||||||||
| Mild | 99 (89.2) | 62 (78.5) | 87 (86.1) | 74 (83.1) | 157 (84.9) | 4 (80.0) | 31 (91.2) | 130 (83.3) | 140 (87.0) | 21 (72.4) | |||||
| Moderate | 11 (9.9) | 15 (19.0) | 12 (11.9) | 14 (15.7) | 25 (13.5) | 1 (20.0) | 2 (5.9) | 24 (15.4) | 19 (11.8) | 7 (24.1) | |||||
| Marked | 1 (0.9) | 2 (2.5) | 2 (2.0) | 1 (1.1) | 3 (1.6) | 0 (0.0) | 1 (2.9) | 2 (1.3) | 2 (1.2) | 1 (3.4) | |||||
| Stromal mitosis | 1.175 | 2.905 | 4.415 | 3.370 | 3.165 | ||||||||||
| 0–4 / 10 HPFs | 96 (86.5) | 63 (79.7) | 86 (85.1) | 73 (82.0) | 155 (83.8) | 4 (80.0) | 30 (88.2) | 129 (82.7) | 136 (84.5) | 23 (79.3) | |||||
| 5–9 / 10 HPFs | 14 (12.6) | 15 (19.0) | 14 (13.9) | 15 (16.9) | 28 (15.1) | 1 (20.0) | 3 (8.8) | 26 (16.7) | 23 (14.3) | 6 (20.7) | |||||
| ≥10 / 10 HPFs | 1 (0.9) | 1 (1.3) | 1 (1.0) | 1 (1.1) | 2 (1.1) | 0 (0.0) | 1 (2.9) | 1 (0.6) | 2 (1.2) | 0 (0.0) | |||||
| Stromal overgrowth | 2.855 | 5.000 | 5.000 | 2.240 | 5.000 | ||||||||||
| Absent | 110 (99.1) | 77 (97.5) | 99 (98.0) | 88 (98.9) | 182 (98.4) | 5 (100.0) | ; | 33 (97.1) | 154 (98.7) | 158 (98.1) | 29 (100.0) | ||||
| Present | 1 (0.9) | 2 (2.5) | 2 (2.0) | 1 (1.1) | 3 (1.6) | 0 (0.0) | 1 (2.9) | 2 (1.3) | 3 (1.9) | 0 (0.0) | |||||
| Tumor margin | 5.000 | 3.945 | 0.220 | 5.000 | 3.495 | ||||||||||
| Circumscribed | 103 (92.8) | 73 (92.4) | 93 (92.1) | 83 (93.3) | 173 (93.5) | 3 (60.0) | 32 (94.1) | 144 (92.3) | 148 (91.9) | 28 (96.6) | |||||
| Infiltrative | 8 (7.2) | 6 (7.6) | 8 (7.9) | 6 (6.7) | 12 (6.5) | 2 (40.0) | 2 (5.9) | 12 (7.7) | 13 (8.1) | 1 (3.4) | |||||
| Tumor recurrence | 9 (8.1) | 3 (3.8) | 1.825 | 5 (5.0) | 7 (7.9) | 2.765 | 12 (6.5) | 0 (0.0) | 5.000 | 3 (8.8) | 9 (5.8) | 2.265 | 12 (7.5) | 0 (0.0) | 1.095 |
| Distance metastasis | 2 (1.8) | 0 (0.0) | 2.560 | 1 (1.0) | 1 (1.1) | 5.000 | 2 (1.1) | 0 (0.0) | 5.000 | 0 (0.0) | 2 (1.3) | 5.000 | 2 (1.2) | 0 (0.0) | 5.000 |
*
14 cases without an epithelial component were excluded.