Table 6.
Independent prognostic factors for disease-free survival and overall survival by multivariate analysis
| Parameter | Disease-free survival | Overall survival | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Hazard ratio | 95% CI | P-value | Hazard ratio | 95% CI | P-value | |
| Stromal cellularity | 0.922 | 0.208 | ||||
| Mild vs. moderate/marked | 0.905 | 0.123-6.659 | 10.054 | 0.278-364.219 | ||
| Stromal atypia | 0.951 | 0.614 | ||||
| Mild vs. moderate/marked | 0.935 | 0.107-8.163 | 0.519 | 0.041-6.631 | ||
| Stromal mitosis | 0.972 | 0.447 | ||||
| 0-4 / 10 HPFs vs. ≥5 / 10 HPFs | 1.057 | 0.046-24.176 | 0.172 | 0.002-16.017 | ||
| Stromal overgrowth | 0.007 | 0.001 | ||||
| Absent vs. present | 12.381 | 1.991-76.978 | 111.262 | 6.175-2004.642 | ||
| Tumor margin | 0.693 | 0.514 | ||||
| Circumscribed vs. Infiltrative | 0.752 | 0.183-3.091 | 0.575 | 0.109-3.038 | ||
| Nuclear beclin-1 (S) | 0.046 | 0.321 | ||||
| Negative vs. Positive | 3.558 | 1.023-12.371 | 3.380 | 0.305-37.446 | ||
| LC3A (S) | 0.263 | 0.296 | ||||
| Negative vs. Positive | 1.905 | 0.616-5.890 | 3.776 | 0.312-45.721 | ||
| p62 (S) | 0.457 | 0.249 | ||||
| Negative vs. Positive | 1.500 | 0.516-4.364 | 3.056 | 0.458-20.406 | ||
S, stromal component.