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. 2013 Oct;3(5):451–463. doi: 10.1089/brain.2013.0147

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Copyright 2013, Mary Ann Liebert, Inc.

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FIG. 1. — The Network Modification (NeMo) tool workflow. The user inputs a mask of white matter (WM) pathology/alteration, which is then transformed into MNI space if needed using Statistical Parametric Mapping's non-linear normalization routine. The Tractogram Reference Set (TRS) is searched for streamlines traveling through areas with altered WM integrity. Two outputs are generated: (1) the regional connectivity changes in the form of the weighted proportion of tracts connecting to a region which travel through the alteration mask, that is, Change in Connectivity (ChaCo) scores, and (2) the global network changes in the form of metrics on the connectivity network matrices corresponding to that alteration mask. The top of the middle panel provides a snapshot of the online version of the NeMo Tool.