Table 3.
Incidence of chemotherapy, surgery, and acute radiotherapy toxicity
| No. of instances (% of total [n = 41]) per grade | |||||
|---|---|---|---|---|---|
| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
| Allergy/immunology | 1 | 2 | 0 | 0 | 0 |
| Auditory/hearing | 0 | 1 | 0 | 0 | 0 |
| Blood/bone marrow | 16 | 14 | 9 | 1 | 0 |
| Cardiovascular (arrhythmia) | 2 | 0 | 1 | 0 | 0 |
| Cardiovascular (general) | 6 | 3 | 2 | 1 | 1* |
| Constitutional symptoms | 7 | 28 | 4 | 0 | 0 |
| Dermatology/skin | 4 | 24 | 2 | 0 | 0 |
| Gastrointestinal | 1 | 20 | 17 | 2 | 1† |
| Hemorrhage | 2 | 0 | 0 | 0 | 0 |
| Hepatic | 7 | 8 | 3 | 0 | 0 |
| Infection/febrile neutropenia | 1 | 6 | 2 | 1 | 0 |
| Lymphatics | 0 | 1 | 0 | 0 | 0 |
| Metabolic/laboratory | 19 | 12 | 6 | 0 | 0 |
| Musculoskeletal | 1 | 1 | 0 | 0 | 0 |
| Neurology | 13 | 14 | 3 | 0 | 0 |
| Ocular/visual | 1 | 0 | 0 | 0 | 0 |
| Pain | 5 | 16 | 8 | 0 | 0 |
| Pulmonary | 7 | 6 | 2 | 2 | 2‡ |
| Renal/genitourinary | 7 | 5 | 1 | 0 | 0 |
| Worst nonhematologic | 0 (0) | 13 (32) | 21 (51) | 3 (7) | 4 (10) |
| Worst overall | 0 (0) | 12 (29) | 21 (51) | 4 (10) | 4 (10) |
*
Patient died 27 days after the start of induction chemotherapy of multiorgan failure from progressive upper extremity thrombosis from a central line.
†
Patient died from an esophageal leak 24 days after surgery.
‡
Both patients died from pneumonitis; 1patient died 57 days after the start of induction chemotherapy (no chemoradiotherapy or surgery), and the other patient died 179 days after the start of chemoradiotherapy (no surgery).