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ITC and in vitro reconstitution results that compare Pks4 wild type (wild type refers to C117A SAT inactive mutant) with KS surface mutants. (A) ITC results show that interactions between Pks4 S0KM WT and ACP are disrupted with the KS surface mutant R582E. (B) Similarly, in vitro reconstitution shows that the surface mutant K593E disrupts interactions with ACP, whose in vitro activity is rescued by the K593Q mutant.
