Dose-dependent effect of pregnane glycosides with different C12 moeities on corticosteroid production by H295R cells. Individual compounds contained various C12 side moieties (null, acetyl, benzoyl, cinnamoyl, nicotinoyl, or tigloyl) and shared a bbbbb (five cymarose units) glycosylation pattern with the exception of ikemagenin that contained a bcca (one cymarose, two oleandrose, and one digitoxose unit) glycosylation side chain.