. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: J Cell Physiol. 2013 May;228(5):1120–1126. doi: 10.1002/jcp.24262

TABLE 2.

Changes in steroidogenic metabolite secretion by H295R cells in response to forskolin stimulation and precursor feeding following the treatment with 10 μM ikemagenin (Ik)

	Steroidogenic metabolite, ng/4×10⁵ cells/24 h
Treatment	Pre	Pro	17Pro	And	11Cor	Cor	Cos
Forskoline (F)	Tr	82±16	21±4	720±21	8±1	2,932±185	82±8
F+Ik	Tr	12±4^*	29±4^*	197±16^*	8±1	226±4^*	25±1^*
F+Ik+Cholesterol	Tr	70±4^**	333±21^**	514±37^**	66±8^**	925±95^**	33±1
F+Ik+Pregnenolone	Fd	350±185^**	2,890±259^**	461±99^**	1,028±197^**	880±378^**	21±4
F+Ik+Progesterone	Tr	Fd	4,363±596^**	234±29	1,908±16^**	428±148	20±4
F+Ik+Deoxycorticosterone	Tr	49±16	115±33	196±8	Fd	354±197	22±2

Tr, trace amount; Fd, precursor feeding.

Significantly different from forskolin value.

^**

Significantly different from forskolin+Ik value (P<0.05).