Panel A. Shown are total bone marrow cell numbers, hematopoietic colony forming activity (CFU-counts) of bone marrow cells and PC lung burden from IFrag−/− (IFNAR−/−/RAG−/−) and RAG−/− mice (IFNAR+/+/RAG−/−) over the course of Pneumocystis lung infection at day 0, 7, 10 and 16 post infection. Panel B. Comparative analysis of total bone marrow cell numbers, hematopoietic colony forming activity (CFU-counts) of bone marrow cells and PC lung burden from lymphocyte-competent IFNAR−/− (IFNAR−/−/RAG+/+) mice and wildtype mice (IFNAR+/+/RAG+/+) over the course of Pneumocystis lung infection at day 0, 7, 10 and 16 post infection. Panel C. Demonstrated are total spleen counts and hematopoietic colony forming activity (CFU-counts) of spleen cells from IFNAR−/− and wildtype mice as a measure for extramedullary hematopoiesis at day 0, 7 10 and 16 post infection. Statistical analysis was performed using a 2-way ANOVA. Comparisons were made between groups at the same time point. P values are marked as * p< 0.05, ** p<0.01, *** p<0.001.