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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Immunol. 2013 Aug 23;191(7):3884–3895. doi: 10.4049/jimmunol.1301344

Figure 4. IFNAR−/− and IFrag−/− show elevated serum IFNγ levels during early responses to Pneumocystis lung infection which correlate with induction of bone marrow stress.

Figure 4

IFNγ serum evaluated over the course of Pneumocystis lung infection in IFNAR−/−, IFrag−/−, wildtype and RAG−/− mice at day 0, 7 10 and 16 post infection using a plate based ELISA assay. Figure 4A compares serum IFNγ responses between lymphocyte-competent IFNAR−/− and wildtype mice, Figure 4B compares serum IFNγ responses between lymphocyte-competent IFrag−/− and RAG−/− mice. Statistical analysis was performed using a 2-way ANOVA. Comparisons were made between groups at the same time point. P values are marked as * p< 0.05, ** p<0.01, *** p<0.001.