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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Immunol. 2013 Aug 23;191(7):3884–3895. doi: 10.4049/jimmunol.1301344

Figure 5.

Figure 5

Crypotococcus neoformans lung infection does not induce bone marrow failure in IFrag−/− mice and also does not induce a systemic IFNγ serum response.

Figure 5A compares total bone marrow cell numbers of IFrag−/− mice either infected with Cryptococcus neoformans (strain H99) or Pneumocystis at day 0, 7, 10 and 16 post infection. Figure 5B compares serum IFNγ levels between Cryptococcus and Pneumocystis-infected IFrag−/− mice at day 0, 7 and 10 post infection. Statistical analysis was performed using a 2-way ANOVA. Comparisons were made between groups at the same time point. P values are marked as * p< 0.05, ** p<0.01, *** p<0.001.

Figure 5C shows the respective pulmonary fungal burden for Pneumocystis (left axis) and Cryptococcus (right axis) over the respective time course. Statistical analysis was performed using a 1-way ANOVA comparing fungal burdens within the respective groups. P values are marked as * p< 0.05, ** p<0.01, *** p<0.001.