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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Immunol. 2013 Aug 23;191(7):3884–3895. doi: 10.4049/jimmunol.1301344

Figure 7. Anti-IFNγ treatment ameliorates loss of mature neutrophils but cannot prevent the progression of bone marrow failure in lymphocyte-deficient IFrag−/− mice.

Figure 7

IFrag−/− mice were infected with Pneumocystis and received either neutralizing anti-IFNγ (3× weekly 250μg, clone R4-6A2) or no treatment. Total bone marrow cell numbers and cell differentiation was performed and compared between the treated (open circle) and untreated group (closed circle) at day 0, 7, 10 and 16 post infection. Figure 7A shows total bone marrow cell numbers, Figure 7B and C show the percentage of band and segmented neutrophils in the bone marrow of the comparison groups. Statistical analysis was performed using a 2-way ANOVA. Comparisons between the groups were made at each time point. P values are marked as * p< 0.05, ** p<0.01, *** p<0.001.