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Morphological investigations of CCKS-1. (A) Untreated CCKS-1 cells showing a pebble-like shape with cell-cell contact. (B) CCKS-1 cells became spindle-shaped and the cell-cell contacts separated (5ng/ml TGF-β1). (C) Low-dose PTX lead to close cell-cell contacts and pebble-like shaped cells in contrast with the TGF-β1-treated cells (5ng/ml TGF-β1 + 5 nM PTX). TGF-β1, transforming growth factor-β1; PTX, paclitaxel.
