Table II.

Univariate and multivariate Cox regression models for clinicopathological characteristics predicting CSS in 103 patients treated with RNU and ipsilateral bladder cuff for UTUC.

	Univariate			Multivariate
Characteristics	HR	95% CI	P-value	HR	95% CI	P-value
Gender
Male	Reference		Reference
Female	0.906	0.467–1.758	0.771	0.945	0.318–2.805	0.919
Age
Continuous	1.001	0.971–1.033	0.928	0.998	0.922–1.080	0.954
Tumor side
Right	Reference		Reference
Left	0.686	0.379–1.241	0.213	0.475	0.172–1.312	0.151
BT at diagnosis
Yes	Reference		Reference
No	1.014	0.498–1.952	0.968	2.494	0.089–1.794	0.232
C-reactive protein (mg/ml)
Continuous	1.184	1.095–1.281	0.000	1.189	0.933–1.516	0.161
Hemoglobin (mg/ml)
Continuous	1.203	0.732–0.944	0.004	1.133	0.685–1.138	0.337
Histological type, n
Urothelial	Reference		Reference
Non-urothelial	2.036	0.924–4.486	0.078	1.951	0.409–9.320	0.402
Pathological grade, n
1/2	Reference		Reference
3	4.918	1.984–12.191	0.001	2.288	0.266–19.705	0.451
Adjuvant chemotherapy
Yes	Reference		Reference
No	1.183	0.333–2.144	0.723	1.499	0.149–2.989	0.597
Urothelial recurrence
No	Reference		Reference
Yes	0.929	0.511–1.690	0.809	0.648	0.215–1.956	0.442
Non-urothelial recurrence
No	Reference		Reference
Yes	5.750	3.018–10.954	0.000	9.512	2.293–39.464	0.002
Microvascular invasion, n
Absent	Reference		Reference
Present	8.299	3.909–17.618	0.000	3.551	0.585–21.558	0.168
Lymphatic invasion, n
Absent	Reference		Reference
Present	3.953	1.966–7.947	0.000	1.205	0.319–4.553	0.784
pT classification, n
pT0/pTis/pTa/pT1	Reference		Reference
pT2/pT3/pT4	2.619	1.676–4.092	0.000	0.996	0.275–3.611	0.995

CSS, cancer-specific survival; RNU, radical nephroureterectomy; HR, hazard ratio; UTUC, upper tract urothelial carcinoma; pT0/pTis/pTa/pT1, superficial; pT2/pT3/pT4, muscle invasive/non-organ defined.